Decoding Seven Basic Odors by Investigating Pharmacophores and Molecular Features of Odorants (2024)

Background: The odors we perceive are primarily the result of a mixture of odorants. There can be one or multiple odors associated with an odorant. Several studies have attempted to link odorant physicochemical properties to specific olfactory perception; however, no universal rulethat can determine how and to what extent molecular properties affect odor perception exists.
Objective: This study aims to identify important and common features of odorants with seven basic odors (floral, fruity, minty, nutty, pungent, sweet, woody) to comprehend the complex topic ofodors better.
Methods: We adopted an in-silico approach to study key and common odorants features with seven fundamental odors (floral, fruity, minty, nutty, pungent, sweet, and woody). A dataset of 1136 odorants having one of the odors was built and studied.
Results: A set of nineteenstructural features has been proposed to identify seven fundamental odors rapidly. The findings also indicated associations between odors, and specific molecular features associated with each group of odorants and shared spatial distribution of odor features.
Conclusion: This study revealedolfactory associations, unique chemical properties linked with each set of odorants, and a common spatial distribution of odor features for considered odors.

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Keywords:Molecular features;odor;odor network;odorants;pharmacophore;smell

Document Type: Research Article

Publication date:01 October 2022

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Decoding Seven Basic Odors by Investigating Pharmacophores and Molecular Features of Odorants (2024)

FAQs

What are the 7 basic odors? ›

Methods: We adopted an in-silico approach to study key and common odorants features with seven fundamental odors (floral, fruity, minty, nutty, pungent, sweet, and woody).

What are the seven primary classes of olfactory stimulants? ›

These classes are as fol lows: (1) camphoraceous, (2) pungent, (3) ethereal, (4) floral, (5) pepperminty, (6) musky, and (7) putrid.

What are the eight basic types of odors that humans can detect? ›

Now, researchers have used mathematics to describe odors systematically and simplify them into 10 categories: fragrant, woody/resinous, fruity (non-citrus), chemical, minty/peppermint, sweet, popcorn, lemon, pungent and decayed.

What are the 10 primary odors? ›

Scientists have classified odors into 10 basic categories: fragrant, woody/resinous, minty/peppermint, sweet, chemical, popcorn, lemon, fruity (non-citrus), pungent and decayed.

What is the strongest odor? ›

The 10 Worst Odours in the World
  • Hydrogen Sulphide.
  • Fact: Reykjavik, the capital of Iceland, uses geothermal springs beneath the city to provide hot water. ...
  • Raw sewage.
  • Corpse flower.
  • Rotten flesh.
  • Special mention: gangrenous flesh. ...
  • Thioacetone.
  • Durian fruit.
Oct 18, 2017

What is the smelliest odor? ›

Worst Smells on Earth
  • Surströmming. This Swedish delicacy literally means “sour herring”. ...
  • Durian. Durian is a fruit native to Southeast Asia, with an odor that has been described as turpentine, rotten onions, and sewage. ...
  • Nattō. ...
  • Skunk.

What smells are humans most sensitive to? ›

Gas leaks, garlic breath, skunks in the neighborhood—ah, the scent of thiols. The human nose is particularly sensitive to these sulfur-containing compounds, which is no surprise given that they are often associated with things to avoid.

What is the chemistry behind smells? ›

Smell involves about 400 unique receptors. Each of the hundreds of thousands of scents we can detect is made of a mixture of different odor molecules. Each type of molecule may be detected by an array of receptors, creating a puzzle for the brain to solve each time the nose catches a whiff of something new.

How many primary odors are there? ›

For years, humans have had categories for colors, flavors and sounds, but when it comes to the sense of smell, things are a mess. Now, just as there are three primary colors and five basic tastes, researchers propose that odors can fall into 10 basic groups.

How do we identify odors? ›

These molecules stimulate specialized nerve cells, called olfactory sensory neurons, high inside the nose. There are a few million of these cells inside your nose. Each makes one of about 500 different types of odor receptor, enabling it to selectively capture a specific set of odor molecules.

What smell do dogs hate the most? ›

For dogs, citrus scents are the enemy. Citrus scents like lemon, lime, oranges, and grapefruit–especially in high concentrations often found in household cleaners or essential oils–can cause irritation to your pup's respiratory tract, so keep any fresh citrus fruits out of your dog's reach. You know–just in case.

What receptors detect odors? ›

Odorants are first detected in the upper region of the nose by the main olfactory epithelium (OE). In this region, millions of olfactory sensory neurons (OSNs) interact with odor molecules through the odorant receptors (ORs), which belong to the superfamily of G protein-coupled receptors.

What scent do squirrels hate? ›

Now that we know more about them, we'll discuss the scents they hate! The scents on this list are: Peppermint Oil, Capsaicin, Coffee Grounds, White Vinegar, Garlic, Cinnamon, Predator Urine, Irish Springs Soap, Dryer Sheets, and Rosemary.

How many smells can humans recognize? ›

Humans Can Identify More Than 1 Trillion Smells.

What are the six groups of odors? ›

Olfactory qualities

On the basis of the apparent similarities of perceived odour quality or confusions in naming, it was concluded that there were six main odour qualities: fruity, flowery, resinous, spicy, foul, and burned.

What are the 6 types of smell? ›

On the basis of the apparent similarities of perceived odour quality or confusions in naming, it was concluded that there were six main odour qualities: fruity, flowery, resinous, spicy, foul, and burned. Electrical activity can be detected with fine insulated wires inserted into the olfactory bulb.

What are the five basic smells? ›

Here are few for you 👇,
  • fragrant,
  • minty/peppermint,
  • Floral.
  • Woody and resinous.
  • chemical,
  • pungent.
  • decayed and so on..
Apr 18, 2018

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