Smells Like the Flu! - ChemistryViews (2024)

Smells Like the Flu! - ChemistryViews (1)

Author: Meghan Campbell

Mammalian cells produce odor compounds in response to viral infection. Cristina E. Davis and colleagues at the University of California, Davis, USA, discovered that mammalian cells emit a specific set of “smells” upon being infected with influenza viruses. These odors are primarily composed of volatile organic compounds, which can be detected by using gas chromatography/mass spectrometry (GC/MS).

Specifically, circulating B-cells from our immune system are capable of producing chemical odors that appear after viral infection. Most of these compounds are specific to the strain of influenza, and they appear on a distinct time course post-infection. In some cases the researchers were able to detect flu just 6–8 hours after infection. Several of these chemicals appear to be generic influenza biomarkers.

This breakthrough may allow researchers to monitor for flu-associated compounds in exhaled human breath as an asymptomatic measure of viral infection—at a stage earlier than present clinical methods. It also appears that some of the compounds detected may be strain-specific, which could allow for further identification of the new infection.

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Smells Like the Flu! - ChemistryViews (2024)

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Smells Like the Flu! - ChemistryViews? ›

Davis and colleagues at the University of California, Davis, USA, discovered that mammalian cells emit a specific set of “smells” upon being infected with influenza viruses. These odors are primarily composed of volatile organic compounds, which can be detected by using gas chromatography/mass spectrometry (GC/MS).

What is the smell you smell when sick? ›

Scientists have found that dozens of illnesses have a particular smell: Diabetes can make your urine smell like rotten apples, and typhoid turns body odor into the smell of baked bread. Worse, yellow fever apparently makes your skin smell like a butcher's shop, if you can imagine that.

What is parosmia in the flu? ›

Loss of smell—which can be partial or total—in itself is debilitating, but the distortion of sense of smell (parosmia) that can occur as a consequence of a viral upper respiratory tract infection (either alongside a reduction in sense of smell or as a solo symptom) can be very distressing for patients.

Can you smell sickness on someone's breath? ›

Rarely, people can have bad breath because of organ failure. A person with kidney failure may have breath that smells like ammonia or urine. Serious liver disease can make breath smell musty or like garlic and rotten eggs. Compounds that are transported through the blood can also be released through your sweat glands.

Can you smell sickness in yourself? ›

Several diseases have been discovered to harbor signature scents on the body in recent studies, including people with typhoid fever reported to smell like baked bread, people with yellow fever smelling like a butcher's shop and the glandular disease scrofula leaving people smelling like stale beer – subtle scents ...

Why do I keep smelling a sick smell? ›

Phantosmia may be caused by a head injury or upper respiratory infection. It can also be caused by aging, trauma, temporal lobe seizures, inflamed sinuses, brain tumors, certain medications and Parkinson's disease. Phantosmia can also result from COVID-19 infection.

When I open my legs, it smells.? ›

Sweating. Sweating in the groin area can attract fungus and bacteria that can lead to a bad smell. Showering after exercise or athletic activity can help reduce the bad-smelling effects of smells related to sweating.

What is cacosmia? ›

Definition. A hallucination of an unpleasant odor. [ from NCI]

Why do I keep smelling a sickly sweet smell? ›

Phantosmia refers to detecting smells that aren't really there. It's a symptom of many common conditions, including allergies, colds and upper respiratory infections. It could also indicate a brain-related condition, including epilepsy, stroke or Alzheimer's disease.

What is hyperosmia? ›

What Is Hyperosmia? Hyperosmia is an overwhelming sensitivity to smells. There are many reasons behind this change in smell. Some include genetics, hormone changes, and migraines. ‌If you have hyperosmia, your taste may also be affected.

What is the smell in your nose when you're sick? ›

Sinuses become infected when small particles such as dust, pollen, or animal dander enter the nasal passages and become trapped. This can cause inflammation, which leads to a buildup of mucus and bacteria in the sinuses. As the bacteria and mucus accumulate, they produce a foul odor that can smell like rotten eggs.

What smells are associated with illness? ›

“[B]y the sense of smell we can recognize the peculiar perspiration of many diseases, which has an important bearing on their identification.”
  • scrofula – stale beer.
  • typhoid fever – baked bread.
  • yellow fever – a butcher's shop.
  • diphtheria – sweet.
  • diabetic ketosis – a fruity aroma of decomposing apples.
Oct 5, 2017

Why does sick smell so bad? ›

And.. as well known, butyric acid is what gives vomit that distinctive, smell-it-a-mile-off, odor. And this is why we're so good at detecting it. Humans can pick this stuff up at 10 parts per million.

What gets the smell of sick out? ›

Vinegar is one of the best natural cleaning products. It's a natural stain remover, disinfectant and odour remover. Use white or apple cider vinegar. Mix one part vinegar with two parts warm water.

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